| 1. Ronde | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 |  |
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| 2. Ronde | 10.06.2021 | Rocha | - | Central Español | 3:2 | ||||
| 3. Ronde | 20.06.2021 | Atenas | - | Rocha | 0:0 | ||||
| 4. Ronde | 25.06.2021 | Rocha | - | Racing | 2:3 |  |
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| 5. Ronde | 01.07.2021 | Villa Teresa | - | Rocha | 2:2 | ||||
| 6. Ronde | 08.07.2021 | Rocha | - | Juventud de Las Piedras | 2:1 | ||||
| 7. Ronde | 14.07.2021 | Uruguay Montevideo | - | Rocha | 2:1 | ||||
| 8. Ronde | 23.07.2021 | Rocha | - | Rampla Juniors | 2:0 | ||||
| 9. Ronde | 29.07.2021 | Danubio | - | Rocha | 1:0 | ||||
| 10. Ronde | 04.08.2021 | Rocha | - | Albion | 0:2 | ||||
| 11. Ronde | 12.08.2021 | Rocha | - | CA Cerro | 1:3 | ||||
| 12. Ronde | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Ronde | 22.09.2021 | Central Español | - | Rocha | 1:0 | ||||
| 14. Ronde | 30.09.2021 | Rocha | - | Atenas | 0:1 | ||||
| 15. Ronde | 06.10.2021 | Racing | - | Rocha | 3:0 | |
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| 16. Ronde | 14.10.2021 | Rocha | - | Villa Teresa | 1:1 | ||||
| 17. Ronde | 19.10.2021 | Juventud de Las Piedras | - | Rocha | 1:0 | ||||
| 18. Ronde | 27.10.2021 | Rocha | - | Uruguay Montevideo | 1:2 | ||||
| 19. Ronde | 01.11.2021 | Rampla Juniors | - | Rocha | 2:1 |
Uruguay