| 1. Ronde | 16.05.2021 | Deportivo Maldonado | - | Liverpool | 2:4 |  |
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| 2. Ronde | 24.05.2021 | River Plate | - | Liverpool | 3:2 | |
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| 3. Ronde | 29.05.2021 | Liverpool | - | Cerro Largo | 3:0 | ||||
| 4. Ronde | 04.06.2021 | Progreso | - | Liverpool | 1:3 | ||||
| 5. Ronde | 11.06.2021 | Liverpool | - | Sud América | 5:0 | ||||
| 6. Ronde | 17.06.2021 | Plaza Colonia | - | Liverpool | 2:1 | ||||
| 7. Ronde | 22.06.2021 | Liverpool | - | Fénix | 5:2 | ||||
| 8. Ronde | 27.06.2021 | Boston River | - | Liverpool | 1:1 | ||||
| 9. Ronde | 06.07.2021 | Liverpool | - | Montevideo Wanderers | 2:1 |  |
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| 10. Ronde | 12.07.2021 | Rentistas | - | Liverpool | 2:1 | ||||
| 11. Ronde | 25.07.2021 | Liverpool | - | Peñarol | 3:3 | ||||
| 12. Ronde | 01.08.2021 | Montevideo City Torque | - | Liverpool | 0:3 | |
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| 13. Ronde | 08.08.2021 | Liverpool | - | Villa Española | 2:2 | ||||
| 14. Ronde | 15.08.2021 | Nacional | - | Liverpool | 1:0 | |
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| 15. Ronde | 21.08.2021 | Liverpool | - | Cerrito | 3:0 | |
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Uruguay