| 1. Ronde | 21.02.2021 | Orense SC | - | Independiente del Valle | 2:0 | ||||
| 2. Ronde | 02.03.2021 | Delfín SC | - | Orense SC | 1:1 | ||||
| 3. Ronde | 06.03.2021 | Orense SC | - | Aucas | 2:2 |  |
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| 5. Ronde | 23.03.2021 | Deportivo Cuenca | - | Orense SC | 1:0 | ||||
| 7. Ronde | 01.04.2021 | Guayaquil City | - | Orense SC | 4:1 | ||||
| 6. Ronde | 04.04.2021 | Orense SC | - | Manta | 0:1 |  |
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| 8. Ronde | 12.04.2021 | Orense SC | - | Mushuc Runa | 0:2 | |
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| 9. Ronde | 17.04.2021 | Macará | - | Orense SC | 1:0 | ||||
| 10. Ronde | 02.05.2021 | Orense SC | - | Emelec | 2:3 | ||||
| 11. Ronde | 08.05.2021 | Orense SC | - | 9 de Octubre | 3:1 | ||||
| 12. Ronde | 18.05.2021 | Técnico Universitario | - | Orense SC | 1:2 | ||||
| 13. Ronde | 22.05.2021 | Orense SC | - | Universidad Catolica | 0:3 | ||||
| 15. Ronde | 17.07.2021 | Orense SC | - | Olmedo | 0:0 |
Ecuador