| 1. Ronde | 22.08.2021 | EA Guingamp [A-jun] | - | Le Mans FC [A-jun] | 1:3 | ||||
| 2. Ronde | 29.08.2021 | SA Mérignac [A-jun] | - | EA Guingamp [A-jun] | 0:3 | ||||
| 3. Ronde | 05.09.2021 | EA Guingamp [A-jun] | - | USSA Vertou [A-jun] | 2:0 |  |
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| 4. Ronde | 12.09.2021 | Girondins Bordeaux [A-jun] | - | EA Guingamp [A-jun] | 2:1 | ||||
| 5. Ronde | 19.09.2021 | EA Guingamp [A-jun] | - | FC Nantes [A-jun] | 0:3 | ||||
| 6. Ronde | 25.09.2021 | Angers SCO [A-jun] | - | EA Guingamp [A-jun] | 0:3 | ||||
| 7. Ronde | 03.10.2021 | EA Guingamp [A-jun] | - | LB Châteauroux [A-jun] | 2:1 | ||||
| 13. Ronde | 28.11.2021 | Tours FC [A-jun] | - | EA Guingamp [A-jun] | 2:2 | |
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| 14. Ronde | 05.12.2021 | EA Guingamp [A-jun] | - | SA Mérignac [A-jun] | 5:2 | |
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| 15. Ronde | 16.01.2022 | USSA Vertou [A-jun] | - | EA Guingamp [A-jun] | 1:0 | ||||
| 20. Ronde | 05.02.2022 | FC Nantes [A-jun] | - | EA Guingamp [A-jun] | 5:0 | ||||
| 21. Ronde | 13.02.2022 | EA Guingamp [A-jun] | - | Angers SCO [A-jun] | 0:2 | ||||
| 25. Ronde | 01.05.2022 | EA Guingamp [A-jun] | - | Tours FC [A-jun] | 4:0 | |
Frankrijk