| 3. Ronde | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 | ||||
| 4. Ronde | 19.09.2021 | Hamrun Spartans | - | Balzan FC | 0:1 | ||||
| 5. Ronde | 25.09.2021 | Floriana FC | - | Hamrun Spartans | 1:2 |  |
|||
| 6. Ronde | 16.10.2021 | Hamrun Spartans | - | Gżira United | 0:1 | ||||
| 7. Ronde | 23.10.2021 | Gudja United | - | Hamrun Spartans | 1:3 |  |
|||
| 8. Ronde | 30.10.2021 | Hamrun Spartans | - | Sirens FC | 1:0 | ||||
| 9. Ronde | 21.11.2021 | Hibernians FC | - | Hamrun Spartans | 1:0 | ||||
| 10. Ronde | 28.11.2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | |
|||
| 11. Ronde | 05.12.2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 | ||||
| 12. Ronde | 13.12.2021 | Valletta FC | - | Hamrun Spartans | 0:1 | ||||
| 14. Ronde | 17.01.2022 | Hamrun Spartans | - | Mosta FC | 2:1 | ||||
| 15. Ronde | 22.01.2022 | Balzan FC | - | Hamrun Spartans | 2:2 | |
|||
| 20. Ronde | 26.02.2022 | Hamrun Spartans | - | Hibernians FC | 0:0 | |
Ghana