| 7. Ronde | 29.08.2021 | Isidro Metapán | - | Alianza | 1:2 |  |
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| 5. Ronde | 10.09.2021 | Alianza | - | Once Municipal | 1:0 |  |
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| 10. Ronde | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 11. Ronde | 25.09.2021 | Jocoro FC | - | Alianza | 3:3 | ||||
| 12. Ronde | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 18. Ronde | 06.11.2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 19. Ronde | 13.11.2021 | Atlético Marte | - | Alianza | 2:1 | ||||
| 20. Ronde | 18.11.2021 | Alianza | - | Santa Tecla FC | 5:0 | ||||
| 21. Ronde | 21.11.2021 | CD Águila | - | Alianza | 0:1 | ||||
| 22. Ronde | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador