| 1. Ronde | 01.08.2021 | Managua FC | - | Juventus Managua | 0:1 | ||||
| 2. Ronde | 09.08.2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
| 4. Ronde | 22.08.2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 7. Ronde | 13.09.2021 | UNAN Managua | - | Managua FC | 2:3 |  |
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| 8. Ronde | 20.09.2021 | Managua FC | - | Real Madriz | 1:1 |  |
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| 6. Ronde | 23.09.2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
| 9. Ronde | 27.09.2021 | CD Walter Ferretti | - | Managua FC | 0:0 | ||||
| 11. Ronde | 10.10.2021 | Managua FC | - | ART Municipal Jalapa | 3:0 | ||||
| 14. Ronde | 25.10.2021 | Diriangén FC | - | Managua FC | 0:3 | ||||
| 15. Ronde | 31.10.2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
| 17. Ronde | 18.11.2021 | Real Madriz | - | Managua FC | 1:3 | ||||
| 18. Ronde | 22.11.2021 | Managua FC | - | CD Walter Ferretti | 3:1 | |
Nicaragua