| 6. Ronde | 21.08.2021 | Jicaral | - | Santos de Guápiles | 1:1 | ||||
| 7. Ronde | 26.08.2021 | Santos de Guápiles | - | CS Herediano | 2:1 | ||||
| 8. Ronde | 30.08.2021 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 9. Ronde | 08.09.2021 | Santos de Guápiles | - | AD San Carlos | 2:2 | ||||
| 10. Ronde | 12.09.2021 | CS Cartaginés | - | Santos de Guápiles | 1:2 | ||||
| 11. Ronde | 17.09.2021 | Santos de Guápiles | - | Guadalupe | 2:2 | ||||
| 16. Ronde | 17.10.2021 | AD Guanacasteca | - | Santos de Guápiles | 1:3 |
Costa Rica