| 3. Ronde | 12.08.2021 | Isidro Metapán | - | CD Águila | 2:2 |  |
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| 4. Ronde | 14.08.2021 | Jocoro FC | - | Isidro Metapán | 1:0 | ||||
| 5. Ronde | 22.08.2021 | Isidro Metapán | - | Municipal Limeño | 1:0 | |
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| 6. Ronde | 25.08.2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | |
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| 7. Ronde | 29.08.2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 8. Ronde | 12.09.2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 9. Ronde | 16.09.2021 | Isidro Metapán | - | Once Municipal | 0:1 | ||||
| 11. Ronde | 26.09.2021 | Isidro Metapán | - | AD Chalatenango | 1:4 | ||||
| 12. Ronde | 02.10.2021 | Atlético Marte | - | Isidro Metapán | 2:0 | |
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| 13. Ronde | 17.10.2021 | Isidro Metapán | - | Santa Tecla FC | 1:1 | ||||
| 14. Ronde | 21.10.2021 | CD Águila | - | Isidro Metapán | 4:0 | ||||
| 15. Ronde | 24.10.2021 | Isidro Metapán | - | Jocoro FC | 1:1 | ||||
| 16. Ronde | 30.10.2021 | Municipal Limeño | - | Isidro Metapán | 2:2 | ||||
| 17. Ronde | 03.11.2021 | Isidro Metapán | - | Platense Zacatecoluca | 1:0 | |
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| 19. Ronde | 14.11.2021 | Isidro Metapán | - | Luis Ángel Firpo | 2:1 | |
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| 20. Ronde | 18.11.2021 | Once Municipal | - | Isidro Metapán | 1:1 | |
El Salvador