| 4. Ronde | 25.09.2021 | sc Heerenveen [U21] | - | FC Groningen [U21] | 4:2 | ||||
| 5. Ronde | 02.10.2021 | NEC Nijmegen [U21] | - | sc Heerenveen [U21] | 2:1 | ||||
| 6. Ronde | 18.10.2021 | Feyenoord [U21] | - | sc Heerenveen [U21] | 2:0 | ||||
| 8. Ronde | 30.10.2021 | sc Heerenveen [U21] | - | NEC Nijmegen [U21] | 0:3 | ||||
| 10. Ronde | 20.11.2021 | sc Heerenveen [U21] | - | Almere City FC [U21] | 2:4 | ||||
| 11. Ronde | 27.11.2021 | NAC Breda [U21] | - | sc Heerenveen [U21] | 2:3 | ||||
| 9. Ronde | 30.11.2021 | FC Groningen [U21] | - | sc Heerenveen [U21] | 3:2 |
Nederland