| 4. Ronde | 15.02.2022 | Real Cartagena | - | Atlético Huila | 1:1 | ||||
| 6. Ronde | 27.02.2022 | Real Santander | - | Real Cartagena | 1:2 |  |
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| 7. Ronde | 06.03.2022 | Real Cartagena | - | Atlético FC | 0:0 | ||||
| 8. Ronde | 10.03.2022 | Leones FC | - | Real Cartagena | 1:0 | ||||
| 9. Ronde | 19.03.2022 | Real Cartagena | - | Bogotá FC | 1:1 | |
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| 10. Ronde | 28.03.2022 | Orsomarso SC | - | Real Cartagena | 1:2 | ||||
| 11. Ronde | 02.04.2022 | Real Cartagena | - | Llaneros FC | 2:0 | |
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| 12. Ronde | 13.04.2022 | Deportes Quindío | - | Real Cartagena | 5:0 | ||||
| 14. Ronde | 25.04.2022 | Boca Juniors de Cali | - | Real Cartagena | 1:2 | |
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| 15. Ronde | 04.05.2022 | Real Cartagena | - | Valledupar FC | 1:2 | |
Colombia