| 1. Ronde | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 |  |
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| 2. Ronde | 08.08.2021 | CD Águila | - | FAS | 1:1 | ||||
| 3. Ronde | 12.08.2021 | Isidro Metapán | - | CD Águila | 2:2 | |
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| 4. Ronde | 15.08.2021 | CD Águila | - | Atlético Marte | 4:1 |  |
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| 6. Ronde | 26.08.2021 | CD Águila | - | AD Chalatenango | 2:1 | ||||
| 8. Ronde | 12.09.2021 | Municipal Limeño | - | CD Águila | 1:0 | ||||
| 9. Ronde | 16.09.2021 | CD Águila | - | Platense Zacatecoluca | 1:0 | ||||
| 10. Ronde | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 12. Ronde | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 | ||||
| 17. Ronde | 03.11.2021 | AD Chalatenango | - | CD Águila | 1:1 | ||||
| 21. Ronde | 21.11.2021 | CD Águila | - | Alianza | 0:1 | ||||
| 22. Ronde | 27.11.2021 | Luis Ángel Firpo | - | CD Águila | 1:0 |
El Salvador