| 1. Ronde | 20.05.2021 | Unión Huaral | - | Santos FC | 1:3 |  |
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| 2. Ronde | 26.05.2021 | Santos FC | - | Chavelines Juniors | 2:1 | ||||
| 3. Ronde | 30.05.2021 | Deportivo Coopsol | - | Santos FC | 1:0 | ||||
| 4. Ronde | 04.06.2021 | Santos FC | - | Juan Aurich | 0:0 | ||||
| 5. Ronde | 26.06.2021 | Pirata | - | Santos FC | 2:2 | ||||
| 6. Ronde | 03.07.2021 | Santos FC | - | Comerciantes Unidos | 4:2 | ||||
| 7. Ronde | 08.07.2021 | Atlético Grau | - | Santos FC | 4:1 | ||||
| 9. Ronde | 16.07.2021 | Santos FC | - | Llacuabamba | 0:1 | |
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| 10. Ronde | 22.07.2021 | Cultural Santa Rosa | - | Santos FC | 3:0 | |
Colombia