| 9. Ronde | 03.03.2022 | Santos de Guápiles | - | AD Guanacasteca | 2:0 | ||||
| 10. Ronde | 06.03.2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 | ||||
| 1. Ronde | 13.03.2022 | AD Guanacasteca | - | Deportivo Saprissa | 1:2 | ||||
| 11. Ronde | 01.04.2022 | AD Guanacasteca | - | Guadalupe | 1:2 |  |
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| 12. Ronde | 07.04.2022 | Deportivo Saprissa | - | AD Guanacasteca | 2:2 | ||||
| 13. Ronde | 09.04.2022 | AD Guanacasteca | - | Jicaral | 3:2 | ||||
| 15. Ronde | 20.04.2022 | Municipal Grecia | - | AD Guanacasteca | 3:1 | ||||
| 16. Ronde | 24.04.2022 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:2 | ||||
| 17. Ronde | 27.04.2022 | AD Guanacasteca | - | AD San Carlos | 2:3 | ||||
| 18. Ronde | 01.05.2022 | Sporting FC | - | AD Guanacasteca | 0:0 | ||||
| 19. Ronde | 04.05.2022 | AD Guanacasteca | - | CS Herediano | 0:1 | ||||
| 20. Ronde | 07.05.2022 | AD Guanacasteca | - | Santos de Guápiles | 2:0 | ||||
| 21. Ronde | 12.05.2022 | CS Cartaginés | - | AD Guanacasteca | 3:0 | |
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| 22. Ronde | 15.05.2022 | Guadalupe | - | AD Guanacasteca | 0:0 | |
Costa Rica