| 1. Ronde | 01.08.2021 | Luis Ángel Firpo | - | Jocoro FC | 1:1 |  |
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| 2. Ronde | 08.08.2021 | Municipal Limeño | - | Luis Ángel Firpo | 1:1 | ||||
| 8. Ronde | 12.09.2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 9. Ronde | 15.09.2021 | Atlético Marte | - | Luis Ángel Firpo | 1:3 | ||||
| 10. Ronde | 19.09.2021 | Luis Ángel Firpo | - | Santa Tecla FC | 0:0 | ||||
| 11. Ronde | 26.09.2021 | CD Águila | - | Luis Ángel Firpo | 1:1 | ||||
| 12. Ronde | 02.10.2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 14. Ronde | 09.10.2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 | ||||
| 13. Ronde | 17.10.2021 | Luis Ángel Firpo | - | Municipal Limeño | 1:1 | ||||
| 15. Ronde | 24.10.2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 16. Ronde | 31.10.2021 | Luis Ángel Firpo | - | AD Chalatenango | 4:2 | ||||
| 17. Ronde | 02.11.2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 18. Ronde | 07.11.2021 | Luis Ángel Firpo | - | FAS | 2:0 |  |
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| 19. Ronde | 14.11.2021 | Isidro Metapán | - | Luis Ángel Firpo | 2:1 | ||||
| 20. Ronde | 18.11.2021 | Luis Ángel Firpo | - | Atlético Marte | 2:0 | ||||
| 21. Ronde | 21.11.2021 | Santa Tecla FC | - | Luis Ángel Firpo | 2:2 |
El Salvador