| 1. Ronde | 28.08.2021 | SBV Excelsior [U21] | - | Willem II [U21] | 0:1 |  |
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| 3. Ronde | 18.09.2021 | FC Emmen [U21] | - | Willem II [U21] | 3:4 | ||||
| 4. Ronde | 25.09.2021 | Willem II [U21] | - | Alphense Boys [U21] | 5:2 | ||||
| 6. Ronde | 16.10.2021 | Willem II [U21] | - | De Graafschap [U21] | 1:2 | ||||
| 7. Ronde | 22.10.2021 | Vitesse [U21] | - | Willem II [U21] | 1:3 | ||||
| 9. Ronde | 06.11.2021 | Alphense Boys [U21] | - | Willem II [U21] | 0:3 | ||||
| 10. Ronde | 20.11.2021 | Willem II [U21] | - | Vitesse [U21] | 4:1 | ||||
| 11. Ronde | 27.11.2021 | PEC Zwolle [U21] | - | Willem II [U21] | 2:2 | ||||
| 12. Ronde | 05.02.2022 | Willem II [U21] | - | SBV Excelsior [U21] | 1:2 | ||||
| 13. Ronde | 12.02.2022 | Willem II [U21] | - | FC Emmen [U21] | 1:2 |
Nederland