| 1. Ronde | 28.07.2021 | Deportivo Saprissa | - | Santos de Guápiles | 3:0 | ||||
| 2. Ronde | 01.08.2021 | Santos de Guápiles | - | Municipal Grecia | 1:0 | ||||
| 3. Ronde | 09.08.2021 | Sporting FC | - | Santos de Guápiles | 2:1 | ||||
| 11. Ronde | 17.09.2021 | Santos de Guápiles | - | Guadalupe | 2:2 | ||||
| 13. Ronde | 26.09.2021 | Municipal Grecia | - | Santos de Guápiles | 3:2 | ||||
| 14. Ronde | 03.10.2021 | Santos de Guápiles | - | Sporting FC | 5:1 | ||||
| 15. Ronde | 13.10.2021 | LD Alajuelense | - | Santos de Guápiles | 1:0 | ||||
| 16. Ronde | 17.10.2021 | AD Guanacasteca | - | Santos de Guápiles | 1:3 | ||||
| 19. Ronde | 31.10.2021 | Santos de Guápiles | - | Municipal Pérez Zeledón | 3:2 | ||||
| 20. Ronde | 21.11.2021 | AD San Carlos | - | Santos de Guápiles | 2:4 |  |
Costa Rica