| 11. Ronde | 17.03.2022 | Deportivo Pasto | - | Santa Fe | 2:4 |  |
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| 12. Ronde | 22.03.2022 | Santa Fe | - | Atlético Bucaramanga | 3:1 | ||||
| 13. Ronde | 29.03.2022 | Atlético Nacional | - | Santa Fe | 2:1 | ||||
| 14. Ronde | 04.04.2022 | Santa Fe | - | Unión Magdalena | 1:0 |  |
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| 15. Ronde | 10.04.2022 | Envigado FC | - | Santa Fe | 1:0 | ||||
| 16. Ronde | 16.04.2022 | Santa Fe | - | Alianza Petrolera | 0:1 | ||||
| 17. Ronde | 25.04.2022 | Millonarios | - | Santa Fe | 2:1 | ||||
| 18. Ronde | 01.05.2022 | Santa Fe | - | Jaguares de Córdoba | 4:0 | |
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| 19. Ronde | 07.05.2022 | Deportivo Cali | - | Santa Fe | 1:1 |
Colombia