| 1. Ronde | 31.07.2021 | CSD Municipal | - | Deportivo Guastatoya | 1:0 | ||||
| 2. Ronde | 07.08.2021 | Santa Lucía | - | CSD Municipal | 1:1 | ||||
| 3. Ronde | 11.08.2021 | CSD Municipal | - | Deportivo Malacateco | 4:0 |  |
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| 4. Ronde | 14.08.2021 | CSD Municipal | - | Iztapa | 2:2 | ||||
| 5. Ronde | 22.08.2021 | Xelaju MC | - | CSD Municipal | 0:0 | ||||
| 6. Ronde | 25.08.2021 | CSD Municipal | - | Sololá FC | 2:3 | ||||
| 7. Ronde | 29.08.2021 | Nueva Concepción | - | CSD Municipal | 0:2 |  |
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| 9. Ronde | 11.09.2021 | Comunicaciones | - | CSD Municipal | 2:1 | ||||
| 10. Ronde | 18.09.2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 8. Ronde | 29.09.2021 | CSD Municipal | - | Achuapa | 1:0 | ||||
| 12. Ronde | 03.10.2021 | Deportivo Guastatoya | - | CSD Municipal | 1:0 | |
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| 13. Ronde | 09.10.2021 | CSD Municipal | - | Santa Lucía | 1:1 |  |
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| 14. Ronde | 17.10.2021 | Deportivo Malacateco | - | CSD Municipal | 1:0 | ||||
| 15. Ronde | 23.10.2021 | Iztapa | - | CSD Municipal | 1:0 |
Guatemala