| 1. Ronde | 23.02.2025 | Portland Timbers | - | Vancouver Whitecaps | 1:4 | ||||
| 2. Ronde | 02.03.2025 | Portland Timbers | - | Austin FC | 1:0 |  |
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| 3. Ronde | 09.03.2025 | Nashville SC | - | Portland Timbers | 2:0 | ||||
| 5. Ronde | 23.03.2025 | Colorado Rapids | - | Portland Timbers | 0:3 | ||||
| 6. Ronde | 31.03.2025 | Portland Timbers | - | Houston Dynamo | 3:1 | ||||
| 7. Ronde | 06.04.2025 | Austin FC | - | Portland Timbers | 0:0 | ||||
| 9. Ronde | 20.04.2025 | Portland Timbers | - | Los Angeles FC | 3:3 | ||||
| 10. Ronde | 28.04.2025 | Los Angeles Galaxy | - | Portland Timbers | 2:4 | ||||
| 11. Ronde | 04.05.2025 | San Jose Earthquakes | - | Portland Timbers | 4:1 | ||||
| 12. Ronde | 11.05.2025 | Portland Timbers | - | Sporting Kansas City | 1:0 | ||||
| 13. Ronde | 15.05.2025 | Real Salt Lake | - | Portland Timbers | 0:0 | ||||
| 14. Ronde | 18.05.2025 | Portland Timbers | - | Seattle Sounders | 1:1 | ||||
| 16. Ronde | 29.05.2025 | Portland Timbers | - | Colorado Rapids | 2:1 |
Ecuador