| 1. Ronde | 18.01.2021 | Deportes Tolima | - | Once Caldas | 1:1 | ||||
| 6. Ronde | 15.02.2021 | Deportivo Pasto | - | Deportes Tolima | 0:1 | ||||
| 8. Ronde | 20.02.2021 | Deportes Tolima | - | Patriotas FC | 3:1 | ||||
| 2. Ronde | 05.03.2021 | Santa Fe | - | Deportes Tolima | 3:2 | ||||
| 11. Ronde | 08.03.2021 | Boyacá Chicó | - | Deportes Tolima | 2:1 | ||||
| 12. Ronde | 13.03.2021 | Deportes Tolima | - | Jaguares de Córdoba | 3:2 |  |
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| 13. Ronde | 21.03.2021 | Deportivo Cali | - | Deportes Tolima | 0:0 | ||||
| 14. Ronde | 24.03.2021 | Deportes Tolima | - | Atlético Junior | 0:1 | ||||
| 15. Ronde | 27.03.2021 | Envigado FC | - | Deportes Tolima | 0:0 | ||||
| 16. Ronde | 31.03.2021 | Deportes Tolima | - | Atlético Nacional | 2:1 |  |
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| 17. Ronde | 04.04.2021 | Millonarios | - | Deportes Tolima | 0:0 | ||||
| 18. Ronde | 13.04.2021 | Deportes Tolima | - | Atlético Bucaramanga | 0:0 | ||||
| 19. Ronde | 18.04.2021 | América de Cali | - | Deportes Tolima | 2:0 |
Ecuador