| 1. Ronde | 29.07.2021 | CS Herediano | - | Guadalupe | 0:1 | ||||
| 2. Ronde | 01.08.2021 | Jicaral | - | CS Herediano | 3:2 | ||||
| 3. Ronde | 09.08.2021 | Deportivo Saprissa | - | CS Herediano | 2:3 |  |
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| 4. Ronde | 12.08.2021 | CS Herediano | - | Municipal Pérez Zeledón | 1:0 | ||||
| 7. Ronde | 26.08.2021 | Santos de Guápiles | - | CS Herediano | 2:1 | ||||
| 8. Ronde | 29.08.2021 | CS Herediano | - | CS Cartaginés | 2:0 | |
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| 9. Ronde | 09.09.2021 | AD Guanacasteca | - | CS Herediano | 2:1 | ||||
| 10. Ronde | 12.09.2021 | Municipal Grecia | - | CS Herediano | 1:2 | ||||
| 12. Ronde | 19.09.2021 | Guadalupe | - | CS Herediano | 0:2 | ||||
| 14. Ronde | 04.10.2021 | CS Herediano | - | Deportivo Saprissa | 2:1 | ||||
| 15. Ronde | 13.10.2021 | Municipal Pérez Zeledón | - | CS Herediano | 0:1 | |
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| 16. Ronde | 17.10.2021 | CS Herediano | - | LD Alajuelense | 0:0 |  |
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| 17. Ronde | 23.10.2021 | AD San Carlos | - | CS Herediano | 0:0 | |
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| 18. Ronde | 28.10.2021 | CS Herediano | - | Santos de Guápiles | 1:1 | ||||
| 20. Ronde | 22.11.2021 | CS Herediano | - | AD Guanacasteca | 5:0 | ||||
| 22. Ronde | 28.11.2021 | Sporting FC | - | CS Herediano | 0:2 |
Costa Rica