| 1. Ronde | 26.07.2020 | Cruz Azul | - | Santos Laguna | 2:0 |  |
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| 3. Ronde | 09.08.2020 | Cruz Azul | - | Club León | 2:0 | ||||
| 4. Ronde | 13.08.2020 | Gallos Blancos | - | Cruz Azul | 1:0 |  |
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| 5. Ronde | 16.08.2020 | Cruz Azul | - | FC Juárez | 3:2 | |
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| 6. Ronde | 24.08.2020 | Atlético San Luis | - | Cruz Azul | 1:3 | |
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| 7. Ronde | 30.08.2020 | Cruz Azul | - | Club Necaxa | 3:0 | |
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| 8. Ronde | 06.09.2020 | Atlas Guadalajara | - | Cruz Azul | 1:0 | ||||
| 9. Ronde | 10.09.2020 | Cruz Azul | - | CF Pachuca | 1:0 | |
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| 10. Ronde | 14.09.2020 | Club Tijuana | - | Cruz Azul | 1:2 | |
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| 11. Ronde | 19.09.2020 | Mazatlán FC | - | Cruz Azul | 2:3 | |
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| 12. Ronde | 28.09.2020 | Cruz Azul | - | CF América | 0:0 | ||||
| 13. Ronde | 04.10.2020 | Deportivo Toluca | - | Cruz Azul | 2:0 | ||||
| 14. Ronde | 18.10.2020 | Cruz Azul | - | UANL Tigres | 0:2 | ||||
| 15. Ronde | 26.10.2020 | Deportivo Guadalajara | - | Cruz Azul | 0:2 | |
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| 16. Ronde | 01.11.2020 | CF Monterrey | - | Cruz Azul | 1:0 | ||||
| 17. Ronde | 08.11.2020 | Cruz Azul | - | Pumas UNAM | 1:2 |
Uruguay