| 1. Ronde | 01.09.2021 | Cortuluá | - | Real Santander | 2:0 | ||||
| 8. Ronde | 11.09.2021 | Real Santander | - | Barranquilla FC | 1:1 | ||||
| 9. Ronde | 18.09.2021 | Bogotá FC | - | Real Santander | 1:1 | ||||
| 10. Ronde | 24.09.2021 | Real Santander | - | Atlético FC | 0:2 | ||||
| 11. Ronde | 02.10.2021 | Orsomarso SC | - | Real Santander | 3:1 |  |
Colombia