| 1. Ronde | 18.01.2021 | Plaza Colonia | - | Liverpool | 0:0 |  |
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| 2. Ronde | 21.01.2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 4. Ronde | 04.02.2021 | Plaza Colonia | - | CA Cerro | 2:1 | |
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| 6. Ronde | 10.02.2021 | Plaza Colonia | - | Danubio | 3:0 | ||||
| 8. Ronde | 19.02.2021 | Plaza Colonia | - | Boston River | 3:0 | ||||
| 10. Ronde | 01.03.2021 | Plaza Colonia | - | Rentistas | 5:0 | |
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| 12. Ronde | 12.03.2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 |
Uruguay