| 1. Ronde | 09.01.2021 | Mazatlán FC | - | Club Necaxa | 3:2 | ||||
| 5. Ronde | 07.02.2021 | Deportivo Toluca | - | Mazatlán FC | 4:1 | ||||
| 9. Ronde | 04.03.2021 | Cruz Azul | - | Mazatlán FC | 1:0 | ||||
| 10. Ronde | 07.03.2021 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | ||||
| 11. Ronde | 14.03.2021 | UANL Tigres | - | Mazatlán FC | 1:2 | ||||
| 13. Ronde | 03.04.2021 | Puebla FC | - | Mazatlán FC | 3:1 | ||||
| 14. Ronde | 12.04.2021 | Club Tijuana | - | Mazatlán FC | 2:3 | ||||
| 15. Ronde | 17.04.2021 | Mazatlán FC | - | Atlas Guadalajara | 0:0 | ||||
| 16. Ronde | 24.04.2021 | Mazatlán FC | - | Club León | 4:3 |  |
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| 17. Ronde | 02.05.2021 | CF Monterrey | - | Mazatlán FC | 1:0 |
Mexico