| 1. Ronde | 23.01.2010 | River Plate | - | Fénix | 0:1 |  |
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| 3. Ronde | 06.02.2010 | Rampla Juniors | - | River Plate | 2:1 |  |
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| 5. Ronde | 19.02.2010 | Nacional | - | River Plate | 1:4 | |
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| 4. Ronde | 24.02.2010 | River Plate | - | Danubio | 3:0 | |
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| 6. Ronde | 27.02.2010 | River Plate | - | Peñarol | 2:3 | ||||
| 9. Ronde | 21.03.2010 | Liverpool | - | River Plate | 1:1 | |
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| 8. Ronde | 24.03.2010 | River Plate | - | CA Cerro | 0:1 | ||||
| 10. Ronde | 28.03.2010 | River Plate | - | Cerrito | 3:0 | |
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| 11. Ronde | 04.04.2010 | River Plate | - | Tacuarembó | 3:1 | |
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| 13. Ronde | 17.04.2010 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 14. Ronde | 25.04.2010 | River Plate | - | Racing | 4:1 | |
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| 15. Ronde | 02.05.2010 | Montevideo Wanderers | - | River Plate | 2:2 | |
Uruguay