| 14. Ronde | 03.10.2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 | ||||
| 15. Ronde | 13.10.2021 | AD San Carlos | - | CS Cartaginés | 0:1 | ||||
| 16. Ronde | 17.10.2021 | Jicaral | - | AD San Carlos | 0:4 | ||||
| 17. Ronde | 23.10.2021 | AD San Carlos | - | CS Herediano | 0:0 | ||||
| 18. Ronde | 28.10.2021 | AD San Carlos | - | Sporting FC | 3:1 | ||||
| 19. Ronde | 01.11.2021 | AD Guanacasteca | - | AD San Carlos | 0:1 |  |
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| 20. Ronde | 21.11.2021 | AD San Carlos | - | Santos de Guápiles | 2:4 | ||||
| 21. Ronde | 24.11.2021 | Deportivo Saprissa | - | AD San Carlos | 3:0 | ||||
| 22. Ronde | 28.11.2021 | AD San Carlos | - | Municipal Grecia | 1:3 |
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