| ANAPROF | 18.11.20 | Sporting San Miguelito | - | San Francisco FC | 1:2 | ||||
| ANAPROF | 05.09.21 | Veraguas Club Deportivo | - | San Francisco FC | 1:0 | ||||
| ANAPROF | 02.10.21 | San Francisco FC | - | Alianza | 0:1 | ||||
| ANAPROF | 06.11.21 | San Francisco FC | - | Independiente de La Chorrera | 1:1 |  |
 |
||
| ANAPROF | 20.11.21 | San Francisco FC | - | Veraguas Club Deportivo | 0:1 | |
Panama