| 6. Ronde | 08.08.2022 | Deportivo Pereira | - | Santa Fe | 0:1 | ||||
| 14. Ronde | 25.09.2022 | Unión Magdalena | - | Santa Fe | 0:2 | ||||
| 13. Ronde | 30.09.2022 | Santa Fe | - | Atlético Nacional | 1:1 | ||||
| 15. Ronde | 03.10.2022 | Santa Fe | - | Envigado FC | 1:0 | ||||
| 17. Ronde | 06.10.2022 | Santa Fe | - | Millonarios | 3:2 | ||||
| 16. Ronde | 11.10.2022 | Alianza Petrolera | - | Santa Fe | 4:0 | ||||
| 18. Ronde | 17.10.2022 | Jaguares de Córdoba | - | Santa Fe | 2:1 | ||||
| 19. Ronde | 22.10.2022 | Santa Fe | - | Deportivo Cali | 1:0 | ||||
| 20. Ronde | 30.10.2022 | Santa Fe | - | Once Caldas | 2:1 |  |
Colombia