| 1. Ronde | 19.02.2022 | Mushuc Runa | - | Universidad Catolica | 1:2 | ||||
| 4. Ronde | 12.03.2022 | Mushuc Runa | - | Cumbayá | 4:2 | ||||
| 8. Ronde | 16.04.2022 | Gualaceo SC | - | Mushuc Runa | 3:2 | ||||
| 11. Ronde | 30.04.2022 | Mushuc Runa | - | Guayaquil City | 2:0 |  |
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| 12. Ronde | 08.05.2022 | Emelec | - | Mushuc Runa | 4:0 | ||||
| 13. Ronde | 14.05.2022 | Mushuc Runa | - | Aucas | 1:1 | ||||
| 14. Ronde | 23.05.2022 | Independiente del Valle | - | Mushuc Runa | 0:1 | ||||
| 15. Ronde | 28.05.2022 | Mushuc Runa | - | Deportivo Cuenca | 1:0 |
Ecuador