| 2. Ronde | 31.07.2021 | CS Cartaginés | - | AD Guanacasteca | 1:1 | ||||
| 3. Ronde | 08.08.2021 | LD Alajuelense | - | CS Cartaginés | 2:3 |  |
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| 4. Ronde | 11.08.2021 | CS Cartaginés | - | AD San Carlos | 5:1 | |
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| 5. Ronde | 14.08.2021 | Sporting FC | - | CS Cartaginés | 4:1 | ||||
| 6. Ronde | 18.08.2021 | CS Cartaginés | - | Deportivo Saprissa | 1:0 | ||||
| 7. Ronde | 25.08.2021 | CS Cartaginés | - | Guadalupe | 0:1 | ||||
| 8. Ronde | 29.08.2021 | CS Herediano | - | CS Cartaginés | 2:0 | ||||
| 9. Ronde | 08.09.2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 10. Ronde | 12.09.2021 | CS Cartaginés | - | Santos de Guápiles | 1:2 | ||||
| 11. Ronde | 15.09.2021 | Jicaral | - | CS Cartaginés | 0:3 | ||||
| 13. Ronde | 25.09.2021 | AD Guanacasteca | - | CS Cartaginés | 2:1 | ||||
| 21. Ronde | 25.11.2021 | Santos de Guápiles | - | CS Cartaginés | 1:2 | ||||
| 22. Ronde | 28.11.2021 | CS Cartaginés | - | Jicaral | 4:0 |
Costa Rica