| 1. Ronde | 13.01.2022 | Guadalupe | - | CS Cartaginés | 3:2 |  |
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| 2. Ronde | 16.01.2022 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 4. Ronde | 04.02.2022 | CS Cartaginés | - | Sporting FC | 2:1 | ||||
| 5. Ronde | 10.02.2022 | LD Alajuelense | - | CS Cartaginés | 3:2 | ||||
| 6. Ronde | 13.02.2022 | Municipal Grecia | - | CS Cartaginés | 2:0 | ||||
| 7. Ronde | 20.02.2022 | CS Cartaginés | - | CS Herediano | 1:0 | ||||
| 8. Ronde | 28.02.2022 | Santos de Guápiles | - | CS Cartaginés | 1:3 | ||||
| 10. Ronde | 06.03.2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 | ||||
| 11. Ronde | 01.04.2022 | CS Cartaginés | - | Jicaral | 0:0 | ||||
| 12. Ronde | 08.04.2022 | CS Cartaginés | - | Guadalupe | 4:1 | ||||
| 15. Ronde | 21.04.2022 | Sporting FC | - | CS Cartaginés | 2:2 | ||||
| 16. Ronde | 24.04.2022 | CS Cartaginés | - | LD Alajuelense | 1:2 | ||||
| 17. Ronde | 27.04.2022 | CS Cartaginés | - | Municipal Grecia | 4:0 | ||||
| 18. Ronde | 01.05.2022 | CS Herediano | - | CS Cartaginés | 4:1 | |
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| 19. Ronde | 04.05.2022 | CS Cartaginés | - | Santos de Guápiles | 4:1 | ||||
| 20. Ronde | 09.05.2022 | AD San Carlos | - | CS Cartaginés | 3:2 | |
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| 21. Ronde | 12.05.2022 | CS Cartaginés | - | AD Guanacasteca | 3:0 | ||||
| 22. Ronde | 15.05.2022 | Jicaral | - | CS Cartaginés | 4:3 |
Costa Rica