| 1. Ronde | 19.07.2021 | Universidad Cesar Vallejo | - | Cusco FC | 1:0 | ||||
| 3. Ronde | 01.08.2021 | Cusco FC | - | Alianza Universidad | 2:3 | ||||
| 4. Ronde | 04.08.2021 | FBC Melgar | - | Cusco FC | 2:2 | ||||
| 7. Ronde | 17.08.2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 8. Ronde | 23.08.2021 | Sporting Cristal | - | Cusco FC | 4:1 | ||||
| 9. Ronde | 27.08.2021 | Cusco FC | - | Cienciano | 3:0 Toeg. | ||||
| 10. Ronde | 11.09.2021 | Ayacucho FC | - | Cusco FC | 1:3 |  |
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| 11. Ronde | 17.09.2021 | Cusco FC | - | Alianza Lima | 0:2 | ||||
| 12. Ronde | 22.09.2021 | Sport Boys | - | Cusco FC | 3:2 | ||||
| 13. Ronde | 27.09.2021 | Cusco FC | - | Academia Cantolao | 3:2 | ||||
| 14. Ronde | 03.10.2021 | Universidad San Martín | - | Cusco FC | 1:1 | ||||
| 15. Ronde | 18.10.2021 | Cusco FC | - | Deportivo Municipal | 3:5 |
Peru