| 1. Ronde | 13.08.2021 | Hamrun Spartans | - | Valletta FC | 1:2 | ||||
| 2. Ronde | 21.08.2021 | Valletta FC | - | Balzan FC | 1:0 |  |
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| 3. Ronde | 11.09.2021 | Floriana FC | - | Valletta FC | 3:0 | |
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| 5. Ronde | 25.09.2021 | Gudja United | - | Valletta FC | 2:0 |  |
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| 8. Ronde | 30.10.2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 10. Ronde | 27.11.2021 | Valletta FC | - | Mosta FC | 3:1 | ||||
| 11. Ronde | 04.12.2021 | Valletta FC | - | Birkirkara FC | 0:0 | ||||
| 12. Ronde | 13.12.2021 | Valletta FC | - | Hamrun Spartans | 0:1 | ||||
| 13. Ronde | 19.12.2021 | Balzan FC | - | Valletta FC | 2:1 |
Malta