| 1. Ronde | 28.08.2021 | Persipura Jayapura | - | Persita Tangerang | 1:2 | ||||
| 2. Ronde | 10.09.2021 | Persela Lamongan | - | Persipura Jayapura | 1:0 | ||||
| 5. Ronde | 29.09.2021 | Persipura Jayapura | - | Arema Cronus FC | 0:1 | ||||
| 6. Ronde | 03.10.2021 | Madura United | - | Persipura Jayapura | 2:2 | ||||
| 8. Ronde | 21.10.2021 | Persik Kediri | - | Persipura Jayapura | 4:2 | ||||
| 9. Ronde | 25.10.2021 | Persipura Jayapura | - | PS Barito Putera | 0:1 | ||||
| 10. Ronde | 30.10.2021 | Persib Bandung | - | Persipura Jayapura | 3:0 | ||||
| 12. Ronde | 18.11.2021 | Borneo FC | - | Persipura Jayapura | 1:0 |  |
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| 13. Ronde | 22.11.2021 | Persipura Jayapura | - | Persikabo 1973 | 2:1 | ||||
| 14. Ronde | 27.11.2021 | PSM Makassar | - | Persipura Jayapura | 1:1 | ||||
| 15. Ronde | 02.12.2021 | Persipura Jayapura | - | Bhayangkara Presisi Indonesia | 0:2 | ||||
| 16. Ronde | 07.12.2021 | PSS Sleman | - | Persipura Jayapura | 1:1 | ||||
| 23. Ronde | 06.02.2022 | Persebaya Surabaya | - | Persipura Jayapura | 0:2 | ||||
| 27. Ronde | 24.02.2022 | Bali United | - | Persipura Jayapura | 4:1 |
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