| 1. Ronde | 07.02.2022 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 2. Ronde | 14.02.2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 |  |
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| 3. Ronde | 20.02.2022 | Fénix | - | Montevideo Wanderers | 0:3 | |
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| 4. Ronde | 26.02.2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | |
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| 5. Ronde | 13.03.2022 | Albion | - | Montevideo Wanderers | 1:1 | ||||
| 6. Ronde | 20.03.2022 | Montevideo Wanderers | - | Nacional | 2:2 |  |
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| 8. Ronde | 12.04.2022 | Montevideo Wanderers | - | Deportivo Maldonado | 0:1 | ||||
| 9. Ronde | 18.04.2022 | Rentistas | - | Montevideo Wanderers | 1:3 | ||||
| 10. Ronde | 23.04.2022 | Montevideo Wanderers | - | Liverpool | 0:0 |  |
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| 13. Ronde | 22.05.2022 | Cerrito | - | Montevideo Wanderers | 0:2 | ||||
| 14. Ronde | 29.05.2022 | Plaza Colonia | - | Montevideo Wanderers | 1:0 | ||||
| 15. Ronde | 06.06.2022 | Montevideo Wanderers | - | Boston River | 1:2 |
Uruguay