| 1. Ronde | 10.01.2021 | CF América | - | Atlético San Luis | 2:1 | ||||
| 3. Ronde | 22.01.2021 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 |  |
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| 4. Ronde | 02.02.2021 | Club León | - | Atlético San Luis | 3:1 | ||||
| 5. Ronde | 05.02.2021 | Atlético San Luis | - | Club Tijuana | 2:2 |  |
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| 6. Ronde | 13.02.2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
| 7. Ronde | 19.02.2021 | Atlético San Luis | - | Santos Laguna | 1:0 | ||||
| 8. Ronde | 26.02.2021 | Atlético San Luis | - | UANL Tigres | 2:2 | |
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| 9. Ronde | 03.03.2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 10. Ronde | 06.03.2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 11. Ronde | 15.03.2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Ronde | 21.03.2021 | Atlético San Luis | - | Pumas UNAM | 0:1 | ||||
| 13. Ronde | 04.04.2021 | CF Monterrey | - | Atlético San Luis | 2:0 | ||||
| 14. Ronde | 10.04.2021 | FC Juárez | - | Atlético San Luis | 2:1 | ||||
| 15. Ronde | 18.04.2021 | Atlético San Luis | - | Puebla FC | 1:4 | ||||
| 17. Ronde | 30.04.2021 | Atlético San Luis | - | CF Pachuca | 1:5 |
Mexico