| 5. Ronde | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Ronde | 20.03.2022 | River Plate | - | Fénix | 3:1 | ||||
| 8. Ronde | 10.04.2022 | River Plate | - | Albion | 4:1 | ||||
| 13. Ronde | 22.05.2022 | Liverpool | - | River Plate | 2:1 | ||||
| 14. Ronde | 29.05.2022 | River Plate | - | Peñarol | 0:0 | ||||
| 15. Ronde | 04.06.2022 | Montevideo City Torque | - | River Plate | 0:0 |
Uruguay