| 1. Ronde | 02.06.2021 | Central Español | - | Danubio | 0:0 | ||||
| 3. Ronde | 20.06.2021 | Racing | - | Danubio | 2:1 |  |
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| 4. Ronde | 26.06.2021 | Danubio | - | Villa Teresa | 1:0 | ||||
| 6. Ronde | 08.07.2021 | Danubio | - | Uruguay Montevideo | 1:0 | ||||
| 7. Ronde | 16.07.2021 | Rampla Juniors | - | Danubio | 0:0 | ||||
| 8. Ronde | 22.07.2021 | Danubio | - | Albion | 0:2 |  |
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| 9. Ronde | 29.07.2021 | Danubio | - | Rocha | 1:0 | ||||
| 10. Ronde | 06.08.2021 | CA Cerro | - | Danubio | 1:1 | ||||
| 11. Ronde | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 15. Ronde | 05.10.2021 | Villa Teresa | - | Danubio | 0:2 | ||||
| 16. Ronde | 13.10.2021 | Danubio | - | Juventud de Las Piedras | 0:1 | ||||
| 18. Ronde | 28.10.2021 | Danubio | - | Rampla Juniors | 2:0 | ||||
| 19. Ronde | 01.11.2021 | Albion | - | Danubio | 2:1 | |
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| 20. Ronde | 10.11.2021 | Rocha | - | Danubio | 1:2 | ||||
| 22. Ronde | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay