| 2. Ronde | 09.07.2022 | Deportivo Coopsol | - | Santos FC | 0:1 | ||||
| 3. Ronde | 17.07.2022 | Santos FC | - | Unión Huaral | 1:0 | ||||
| 4. Ronde | 23.07.2022 | Juan Aurich | - | Santos FC | 0:1 |  |
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| 6. Ronde | 07.08.2022 | Comerciantes Unidos | - | Santos FC | 1:1 | ||||
| 8. Ronde | 21.08.2022 | Cusco FC | - | Santos FC | 4:1 | ||||
| 9. Ronde | 28.08.2022 | Santos FC | - | Alfonso Ugarte | 1:0 | ||||
| 10. Ronde | 04.09.2022 | Chavelines Juniors | - | Santos FC | 1:2 | |
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| 13. Ronde | 25.09.2022 | Santos FC | - | Los Chankas | 5:0 | |
Peru