| 1. Ronde | 16.01.2021 | Orsomarso SC | - | Barranquilla FC | 2:2 | ||||
| 3. Ronde | 30.01.2021 | Orsomarso SC | - | Llaneros FC | 0:0 | ||||
| 5. Ronde | 10.02.2021 | Orsomarso SC | - | Deportes Quindío | 2:1 |  |
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| 6. Ronde | 15.02.2021 | Tigres FC | - | Orsomarso SC | 2:0 | |
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| 7. Ronde | 20.02.2021 | Boca Juniors de Cali | - | Orsomarso SC | 0:0 | ||||
| 10. Ronde | 07.03.2021 | Orsomarso SC | - | Bogotá FC | 4:2 | |
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| 12. Ronde | 22.03.2021 | Orsomarso SC | - | Leones FC | 1:1 | |
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| 13. Ronde | 27.03.2021 | Atlético Huila | - | Orsomarso SC | 3:2 | |
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| 15. Ronde | 09.04.2021 | Atlético FC | - | Orsomarso SC | 0:0 |  |
Colombia