| 1. Ronde | 23.01.2022 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 2. Ronde | 01.02.2022 | Real Cartagena | - | Fortaleza FC | 1:1 | ||||
| 3. Ronde | 06.02.2022 | Barranquilla FC | - | Real Cartagena | 0:2 |  |
|||
| 6. Ronde | 27.02.2022 | Real Santander | - | Real Cartagena | 1:2 | ||||
| 9. Ronde | 19.03.2022 | Real Cartagena | - | Bogotá FC | 1:1 | |
|||
| 10. Ronde | 28.03.2022 | Orsomarso SC | - | Real Cartagena | 1:2 | ||||
| 11. Ronde | 02.04.2022 | Real Cartagena | - | Llaneros FC | 2:0 | ||||
| 12. Ronde | 13.04.2022 | Deportes Quindío | - | Real Cartagena | 5:0 | |
|||
| 13. Ronde | 20.04.2022 | Real Cartagena | - | Boyacá Chicó | 3:1 | |
|||
| 14. Ronde | 25.04.2022 | Boca Juniors de Cali | - | Real Cartagena | 1:2 |
Colombia