| 1. Ronde | 11.09.2021 | River Plate | - | Cerrito | 1:0 |  |
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| 2. Ronde | 18.09.2021 | Cerrito | - | Cerro Largo | 1:1 | ||||
| 3. Ronde | 26.09.2021 | Progreso | - | Cerrito | 0:1 | ||||
| 4. Ronde | 02.10.2021 | Cerrito | - | Sud América | 2:0 | ||||
| 5. Ronde | 11.10.2021 | Plaza Colonia | - | Cerrito | 3:3 |  |
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| 6. Ronde | 17.10.2021 | Cerrito | - | Fénix | 2:4 | ||||
| 7. Ronde | 21.10.2021 | Boston River | - | Cerrito | 3:2 | ||||
| 8. Ronde | 24.10.2021 | Cerrito | - | Montevideo Wanderers | 2:2 | ||||
| 9. Ronde | 29.10.2021 | Rentistas | - | Cerrito | 1:2 | ||||
| 10. Ronde | 05.11.2021 | Cerrito | - | Peñarol | 1:3 | ||||
| 11. Ronde | 07.11.2021 | Cerrito | - | Montevideo City Torque | 0:2 | ||||
| 13. Ronde | 19.11.2021 | Nacional | - | Cerrito | 1:0 | ||||
| 14. Ronde | 25.11.2021 | Deportivo Maldonado | - | Cerrito | 0:1 | ||||
| 15. Ronde | 06.12.2021 | Cerrito | - | Liverpool | 2:1 |
Uruguay