| 1. Ronde | 16.01.2022 | Alianza | - | Isidro Metapán | 0:2 | ||||
| 2. Ronde | 22.01.2022 | Jocoro FC | - | Alianza | 3:2 | ||||
| 3. Ronde | 27.01.2022 | Alianza | - | AD Chalatenango | 3:1 | ||||
| 5. Ronde | 06.02.2022 | Alianza | - | Luis Ángel Firpo | 0:0 | ||||
| 6. Ronde | 10.02.2022 | Santa Tecla FC | - | Alianza | 2:3 | ||||
| 10. Ronde | 27.02.2022 | Alianza | - | Atlético Marte | 3:2 | ||||
| 4. Ronde | 03.03.2022 | Alianza | - | FAS | 1:1 | ||||
| 11. Ronde | 06.03.2022 | Alianza | - | CD Águila | 0:0 | ||||
| 12. Ronde | 13.03.2022 | Isidro Metapán | - | Alianza | 0:0 | ||||
| 13. Ronde | 20.03.2022 | Alianza | - | Jocoro FC | 2:1 | ||||
| 14. Ronde | 25.03.2022 | AD Chalatenango | - | Alianza | 2:0 |  |
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| 15. Ronde | 03.04.2022 | FAS | - | Alianza | 1:3 |  |
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| 16. Ronde | 10.04.2022 | Luis Ángel Firpo | - | Alianza | 0:1 | ||||
| 17. Ronde | 13.04.2022 | Alianza | - | Santa Tecla FC | 2:2 | |
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| 18. Ronde | 17.04.2022 | Platense Zacatecoluca | - | Alianza | 0:1 | |
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| 19. Ronde | 24.04.2022 | Alianza | - | Municipal Limeño | 4:0 | ||||
| 20. Ronde | 29.04.2022 | Alianza | - | Once Municipal | 1:0 | ||||
| 21. Ronde | 01.05.2022 | Atlético Marte | - | Alianza | 0:3 |
El Salvador