| 1. Ronde | 01.02.2025 | Real Santander | - | Tigres FC | 1:0 | ||||
| 2. Ronde | 11.02.2025 | Barranquilla FC | - | Real Santander | 1:2 | ||||
| 3. Ronde | 15.02.2025 | Real Santander | - | Real Soacha Cundinamarca | 3:4 |  |
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| 4. Ronde | 22.02.2025 | Bogotá FC | - | Real Santander | 2:1 | ||||
| 5. Ronde | 01.03.2025 | Real Santander | - | Jaguares de Córdoba | 0:1 | ||||
| 6. Ronde | 09.03.2025 | Real Cartagena | - | Real Santander | 2:0 | ||||
| 7. Ronde | 17.03.2025 | Real Santander | - | Leones FC | 1:0 | |
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| 8. Ronde | 22.03.2025 | Boca Juniors de Cali | - | Real Santander | 0:1 | |
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| 9. Ronde | 31.03.2025 | Real Santander | - | Cúcuta Deportivo | 2:1 |  |
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| 10. Ronde | 06.04.2025 | Real Santander | - | Orsomarso SC | 0:0 | |
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| 12. Ronde | 19.04.2025 | Real Santander | - | Patriotas FC | 1:1 | ||||
| 13. Ronde | 27.04.2025 | Deportes Quindío | - | Real Santander | 4:2 |
Colombia