| 3. Ronde | 08.08.2021 | Boca Juniors de Cali | - | Real Santander | 0:0 | ||||
| 4. Ronde | 14.08.2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
| 5. Ronde | 20.08.2021 | Leones FC | - | Real Santander | 2:1 | ||||
| 6. Ronde | 28.08.2021 | Real Santander | - | Llaneros FC | 3:1 | ||||
| 1. Ronde | 01.09.2021 | Cortuluá | - | Real Santander | 2:0 | ||||
| 7. Ronde | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 9. Ronde | 18.09.2021 | Bogotá FC | - | Real Santander | 1:1 | ||||
| 10. Ronde | 24.09.2021 | Real Santander | - | Atlético FC | 0:2 |  |
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| 13. Ronde | 20.10.2021 | Boyacá Chicó | - | Real Santander | 3:1 | ||||
| 14. Ronde | 24.10.2021 | Real Santander | - | Fortaleza FC | 1:1 |
Colombia