| 1. Ronde | 23.01.2022 | Valledupar FC | - | Real Santander | 1:0 | ||||
| 2. Ronde | 30.01.2022 | Real Santander | - | Tigres FC | 0:0 | ||||
| 4. Ronde | 13.02.2022 | Real Santander | - | Barranquilla FC | 2:3 | ||||
| 6. Ronde | 27.02.2022 | Real Santander | - | Real Cartagena | 1:2 |  |
|||
| 8. Ronde | 10.03.2022 | Atlético FC | - | Real Santander | 0:1 | ||||
| 9. Ronde | 21.03.2022 | Real Santander | - | Leones FC | 0:4 | ||||
| 10. Ronde | 26.03.2022 | Bogotá FC | - | Real Santander | 2:1 | ||||
| 14. Ronde | 26.04.2022 | Boyacá Chicó | - | Real Santander | 2:1 | ||||
| 15. Ronde | 03.05.2022 | Real Santander | - | Boca Juniors de Cali | 1:1 |
Colombia