| 2. Ronde | 02.08.2021 | Pirin Blagoevgrad | - | PFC Beroe | 2:3 | ||||
| 4. Ronde | 13.08.2021 | Pirin Blagoevgrad | - | CSKA 1948 Sofia | 4:1 | ||||
| 5. Ronde | 22.08.2021 | CSKA Sofia | - | Pirin Blagoevgrad | 1:0 | ||||
| 9. Ronde | 27.09.2021 | Pirin Blagoevgrad | - | Cherno More Varna | 2:2 |  |
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| 11. Ronde | 15.10.2021 | Pirin Blagoevgrad | - | Botev Vratsa | 3:1 | ||||
| 13. Ronde | 31.10.2021 | Pirin Blagoevgrad | - | Tsarsko Selo Sofia | 2:1 | ||||
| 14. Ronde | 06.11.2021 | Pirin Blagoevgrad | - | Botev Plovdiv | 0:1 | ||||
| 15. Ronde | 19.11.2021 | PFC Beroe | - | Pirin Blagoevgrad | 1:1 | ||||
| 16. Ronde | 27.11.2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 | ||||
| 17. Ronde | 02.12.2021 | CSKA 1948 Sofia | - | Pirin Blagoevgrad | 1:0 | ||||
| 18. Ronde | 05.12.2021 | Pirin Blagoevgrad | - | CSKA Sofia | 1:1 | ||||
| 20. Ronde | 21.02.2022 | Pirin Blagoevgrad | - | Lokomotiv Sofia | 2:1 | ||||
| 21. Ronde | 28.02.2022 | Pirin Blagoevgrad | - | Arda Kardzhali | 1:0 | ||||
| 22. Ronde | 05.03.2022 | Cherno More Varna | - | Pirin Blagoevgrad | 1:1 | ||||
| 23. Ronde | 14.03.2022 | Pirin Blagoevgrad | - | Slavia Sofia | 0:0 | ||||
| 24. Ronde | 20.03.2022 | Botev Vratsa | - | Pirin Blagoevgrad | 0:3 |
Bulgarije