| 2. Ronde | 25.07.2021 | Atlético Nacional | - | Deportes Tolima | 1:0 | ||||
| 3. Ronde | 31.07.2021 | Deportes Tolima | - | Alianza Petrolera | 1:1 |  |
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| 4. Ronde | 09.08.2021 | Atlético Junior | - | Deportes Tolima | 0:0 | ||||
| 5. Ronde | 14.08.2021 | Deportes Tolima | - | Deportivo Pasto | 1:0 | ||||
| 6. Ronde | 22.08.2021 | La Equidad | - | Deportes Tolima | 1:1 | ||||
| 7. Ronde | 30.08.2021 | Jaguares de Córdoba | - | Deportes Tolima | 0:3 | ||||
| 8. Ronde | 07.09.2021 | Deportes Tolima | - | Envigado FC | 2:0 | ||||
| 9. Ronde | 14.09.2021 | Atlético Huila | - | Deportes Tolima | 1:2 | ||||
| 10. Ronde | 19.09.2021 | Deportes Tolima | - | Deportivo Cali | 1:1 |  |
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| 11. Ronde | 26.09.2021 | Patriotas FC | - | Deportes Tolima | 0:0 | ||||
| 12. Ronde | 02.10.2021 | Deportes Tolima | - | Santa Fe | 0:0 | ||||
| 13. Ronde | 09.10.2021 | Once Caldas | - | Deportes Tolima | 0:2 | |
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| 14. Ronde | 16.10.2021 | Deportes Tolima | - | Atlético Huila | 1:0 | |
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| 15. Ronde | 24.10.2021 | Independiente Medellín | - | Deportes Tolima | 2:2 | |
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| 16. Ronde | 29.10.2021 | Deportes Tolima | - | América de Cali | 0:1 | ||||
| 20. Ronde | 21.11.2021 | Deportes Tolima | - | Deportes Quindío | 3:1 |
Colombia